Tamao Endo Selected Research

Muscular Dystrophies (Muscular Dystrophy)

1/2022	CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model.
10/2021	PCYT2 synthesizes CDP-glycerol in mammals and reduced PCYT2 enhances the expression of functionally glycosylated α-dystroglycan.
7/2021	The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan.
1/2020	Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.
1/2020	FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1.
1/2019	Mammalian O-mannosyl glycans: Biochemistry and glycopathology.
1/2018	Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.
1/2018	CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan.
10/2017	Glycosylation with ribitol-phosphate in mammals: New insights into the O-mannosyl glycan.
4/2017	3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.

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Tamao Endo Research Topics

Disease

34	Muscular Dystrophies (Muscular Dystrophy) 01/2022 - 03/2002
20	Walker-Warburg Syndrome 01/2016 - 03/2002
6	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 02/2006
3	Eye Abnormalities (Eye Abnormality) 10/2010 - 10/2004
2	Neoplasms (Cancer) 10/2021 - 08/2012
2	Diabetic Nephropathies (Diabetic Nephropathy) 12/2019 - 09/2011
2	Infections 11/2011 - 01/2005
2	Ischemia 02/2011 - 06/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2005 - 04/2004
1	Cardiomyopathies (Cardiomyopathy) 01/2022
1	Drug-Related Side Effects and Adverse Reactions 08/2021
1	Malnutrition (Nutritional Deficiencies) 08/2021
1	Hypoxia (Hypoxemia) 12/2019
1	Fibrosis (Cirrhosis) 12/2019
1	Type 2 Diabetes Mellitus (MODY) 11/2019
1	Amyloidosis 10/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Nephritis 01/2018
1	Lymphoma (Lymphomas) 04/2017
1	Ulcerative Colitis 04/2017
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 04/2016
1	Lissencephaly 03/2016
1	Inflammation (Inflammations) 01/2015
1	Melanoma (Melanoma, Malignant) 08/2012
1	Chromosome Duplication 04/2011
1	Intellectual Disability (Idiocy) 04/2011
1	Heart Arrest (Cardiac Arrest) 02/2011
1	Neuroblastoma 01/2010
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 02/2009
1	Amyloid Plaque 03/2008
1	Brain Injuries (Brain Injury) 06/2005
1	Infected Aneurysm 01/2005
1	Rupture 01/2005
1	False Aneurysm (Pseudoaneurysm) 01/2005
1	Group II Malformations of Cortical Development 01/2004
1	Hydrocephalus (Hydrocephaly) 03/2003
1	Arteriosclerosis 09/2002
1	Protein Deficiency 09/2002

Drug/Important Bio-Agent (IBA)

22	Dystroglycans (Dystroglycan)IBA 01/2022 - 03/2002
19	Proteins (Proteins, Gene)FDA Link 08/2021 - 01/2004
18	Polysaccharides (Glycans)IBA 10/2021 - 10/2003
14	protein O-mannose beta-1,2-N-acetylglucosaminyltransferaseIBA 01/2020 - 03/2002
4	RibitolIBA 01/2022 - 03/2016
4	Mannose (D-Mannose)IBA 01/2020 - 10/2010
3	Phosphates (Orthophosphate)IBA 01/2022 - 03/2016
3	Laminin (Merosin)IBA 01/2018 - 04/2005
3	Amyloid (Amyloid Fibrils)IBA 02/2015 - 11/2008
3	LigandsIBA 08/2012 - 10/2010
3	Amyloid beta-PeptidesIBA 01/2010 - 02/2006
2	EnzymesIBA 01/2022 - 01/2006
2	GlycosyltransferasesIBA 01/2016 - 12/2006
2	protein O-mannosyltransferase (dolichyl-phosphate-mannose - protein mannosyltransferase)IBA 01/2008 - 01/2004
2	Glycoproteins (Glycoprotein)IBA 01/2006 - 10/2003
1	ProdrugsIBA 01/2022
1	Terpenes (Terpenoids)IBA 01/2022
1	cytidine diphosphate ribitolIBA 01/2022
1	TransferasesIBA 01/2020
1	Fumarate Hydratase (Fumarase)IBA 12/2019
1	FumaratesIBA 12/2019
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 12/2019
1	Congo RedIBA 10/2019
1	Immunoglobulin A (IgA)IBA 01/2018
1	HaptoglobinsIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	IsotopesIBA 04/2017
1	SugarsIBA 02/2015
1	Pharmaceutical PreparationsIBA 02/2015
1	Peptide Hydrolases (Proteases)FDA Link 02/2015
1	Peptides (Polypeptides)IBA 02/2015
1	O-GlcNAc transferaseIBA 10/2013
1	Epidermal Growth Factor (EGF)IBA 10/2013
1	Alanine (L-Alanine)FDA Link 10/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2012
1	Sulfates (Sulfates, Inorganic)IBA 08/2012
1	SulfotransferasesIBA 08/2012
1	Galectin 1 (LGALS1)IBA 11/2011
1	ActininIBA 09/2011
1	DNA (Deoxyribonucleic Acid)IBA 04/2011
1	Messenger RNA (mRNA)IBA 01/2010
1	CytokinesIBA 03/2008
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 03/2008
1	InterleukinsIBA 03/2008
1	DystrophinIBA 01/2006
1	LectinsIBA 06/2005
1	Nerve Growth Factors (Neurotrophins)IBA 06/2005
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2004
1	MannosyltransferasesIBA 01/2004
1	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase)IBA 06/2003
1	mu-calpainIBA 09/2002
1	SpectrinIBA 09/2002

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2005
2	Drug Therapy (Chemotherapy) 08/2021 - 04/2017
1	Polypharmacy 08/2021
1	Cardiopulmonary Resuscitation (CPR) 02/2011
1	Stents 01/2005
1	Endovascular Aneurysm Repair 01/2005